San Francisco 49ers
The 49ers reached the Super Bowl last season and will be out to avoid the down-year that often follows for the runner up. The heart of their schedule (Week 6 to Week 12) features some very nice matchups both in real life and fantasy. RB Frank Gore will slow down eventually, but this schedule could help him produce another strong season behind one of the best offensive lines in football. After an entire off-season to scout him, it will be interesting to see if teams find a way to deal with QB Colin Kaepernick's unique skill set.
*Jaguars and 49ers will play at Wembley Stadium in London, England.